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25I-NBOMe (2C-I-NBOMe, Cimbi-5) is a psychedelic drug and derivative of the substituted phenethylamine psychedelic 2C-I. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols.
25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-I.
25I-NBOMe has efficacy at the 5-HT receptor where it acts as an unusually potent and selective partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
25I-NBOMe has formal name: 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine. The chemical formula for 25I-NBOMe is C18H22INO3 with a molecular weight of 427.28
25I-NBOMe are not orally active and should be administered sublingually by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. 25I-NBOMe is potent, being active in sub-milligram doses. A common dose of the hydrochloride salt is 600–1,200 µg.
25I-NBOMe effects usually last 6–10 hours if taken sublingually, orally (or on top of your tongue), or buccally (between your gum and your cheek). When it is ingested, effects usually last 4–6 hours. However, effects can last significantly longer depending on dosage; durations longer than 12 hours have been reported.
25I-NBOMe has similar effects to LSD, though users report more negative effects while under the influence and more risk of harm following use as compared to the classical psychedelics.
The toxicity and long-term health effects of recreational 25I-NBOMe use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.
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25I-NBOMe is intended for research and forensic purposes in a controlled laboratory for study only and is NOT intended for human consumption.
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