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U-47700 is an opioid analgesic that acts as a selective agonist of the µ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor and has around 7.5 x the potency of morphine. It has two chiral centers with four stereoisomers.
U-47700 was derived from an earlier opioid AH-7921. U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures.
U-47700 has formal name: 3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide. The chemical formula for U-47700 is C16H22Cl2N2O with a molecular weight of 329.27
U-47700 produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria.
The toxicity and long-term health effects of recreational U-47700 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Also Its effects are considered by some to be similar to those produced by oxycodone.
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U-47700 is intended for research and forensic purposes in a controlled laboratory for study only and is NOT intended for human consumption.
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